Targeted delivery of therapeutics to endothelium
نویسندگان
چکیده
منابع مشابه
Integrin Targeted Delivery of Gene Therapeutics
Integrins have become key targets for molecular imaging and for selective delivery of anti-cancer agents. Here we review recent work concerning the targeted delivery of antisense and siRNA oligonucleotides via integrins. A variety of approaches have been used to link oligonucleotides to ligands capable of binding integrins with high specificity and affinity. This includes direct chemical conjug...
متن کاملTargeted Delivery of siRNA Therapeutics to Malignant Tumors
Over the past 20 years, a diverse group of ligands targeting surface biomarkers or receptors has been identified with several investigated to target siRNA to tumors. Many approaches to developing tumor-homing peptides, RNA and DNA aptamers, and single-chain variable fragment antibodies by using phage display, in vitro evolution, and recombinant antibody methods could not have been imagined by r...
متن کاملNanotechnology for Targeted Delivery in Cancer Therapeutics
Recent advances in nanotechnology has shown tremendous promise to revolutionize cancer therapeutics by generating new therapies that might allow more efficient targeted delivery of anticancer agents to kill cancerous cells or tumors and imaging agents for diagnosis of various cancers. But, before application of nanoparticle-based targeted delivery systems, significant challenges related to clin...
متن کاملTargeted gene delivery to pulmonary endothelium by anti-PECAM antibody.
To achieve efficient systemic gene delivery to the lung with minimal toxicity, a vector was developed by chemically conjugating a cationic polymer, polyethylenimine (PEI), with anti-platelet endothelial cell adhesion molecule (PECAM) antibody (Ab). Transfection of mouse lung endothelial cells with a plasmid expression vector with cDNA to luciferase (pCMVL) complexed with anti-PECAM Ab-PEI conju...
متن کاملFunctionalized CNTs for delivery of therapeutics
Carbon nanotubes (CNTs) are high aspect ratio allotropes of carbon. Because of their unique physical and chemical characteristics, they are nominated for a vast variety of applications in the biomedical field. Their very low solubility is the only problem of them which is solved by different methods of Functionalization. After discoveries in the last few years of the capacity of CNTs to penetra...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell and Tissue Research
سال: 2008
ISSN: 0302-766X,1432-0878
DOI: 10.1007/s00441-008-0676-7